Dosing of cephalosporines in renal failure pateints Research Proposal

Dosing of cephalosporines in renal failure pateints - Research Proposal Example Aim- To understand the dosing of Cephalosporin in Renal failure patients. Method and Design Physical examination- should be performed for edema, ascites, dehydration. Measurement of body weight and height is performed. In obese patients the ideal body weight should be calculated and dose of drug should be planned consequently. Renal function- Estimation of creatine clearance (the volume of blood plasma that is cleared of creatinine in a unit time). Elimination of drugs is directly proportional to GFR (drugs excreted by kidneys). The Cockroft- Gault equation to estimate Clcr for age between 40- 80 years. Clcr (mL/min) = (140-age)x weight in kgs / 72 x serum creatinine (in mg/ dL) x (0.85 for women). Assessment of GFR from serum creatinine level presumes the stability of renal function and also formulate that serum creatinine measurement is constant. If there is alteration in renal function, the creatinine level does not indicate the true clearance. In case of oliguria, Clcr is approxi mated as 10mL/min. In cases with acute renal failure, the non-renal clearance of medicines diminishes by means of time window of renal failure. In the initial course of the therapy, personalized pharmacokinetic dose for patients with severe renal impairment is vital.